Exendin-4 analogs in insulinoma theranostics
نویسندگان
چکیده
منابع مشابه
Evaluation of an [18F]AlF-NOTA Analog of Exendin-4 for Imaging of GLP-1 Receptor in Insulinoma
INTRODUCTION The GLP-1 receptor plays an important role in glucose homeostasis and thus is a very important target for diabetes therapy. The receptor is also overexpressed in insulinoma, a tumor of pancreatic beta-cells. We previously evaluated two fluorine-18-labeled analogs of exendin-4 prepared by conjugation with [(18)F]FBEM (N-[2-(4-[(18)F]fluorobenzamide)ethyl]maleimide). Both compounds d...
متن کاملRadiosynthesis and evaluation of an 18F–labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma
Background Analogues of exendin-4 have been radiolabeled for imaging the glucagon-like peptide type 1 receptors (GLP-1R) which are overexpressed in insulinoma. The aim of this research was to synthesize an 18F-labeled silicon containing exendin-4 peptide (18F-2) and to evaluate its in vitro and in vivo behavior in CHL-GLP-1 receptor positive tumor-bearing mice. 18F-labeled silicon containing ex...
متن کاملCentral GLP-1 and exendin-4 Differences in the central anorectic effects of GLP-1 and exendin-4 in rats
This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online...
متن کاملExendin-4 potently decreases ghrelin levels in fasting rats.
Ghrelin is a potent orexigenic and adipogenic hormone that strongly influences fat deposition and the generation of hunger in obesity. Indeed, hyperghrelinemia appears to promote an increase in food intake as seen in Prader-Willi Syndrome (PWS). Exendin (Ex)-4 is an agonist of the glucagon-like peptide (GLP)-1 receptor (GLP-1r) that has anorexigenic and fat-reducing properties. Here, we report ...
متن کاملINSULINOMA NEW CONCEPTS IN MANAGEMENT
In this report, nine patients with insulinoma who were operated on between 19H5 and I <J<J3 at the Shohada Medical Center affiliated to the Shahid Beheshti University of Medical Sciences in Tehran are presented. There were three males and six females (male to female ratio I :2) and the patients' age ranged from 23 to 60 years old (mean age 37.6 years old). Duration of symptoms was from thr...
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ژورنال
عنوان ژورنال: Journal of Labelled Compounds and Radiopharmaceuticals
سال: 2019
ISSN: 0362-4803
DOI: 10.1002/jlcr.3750